کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497307 1318928 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary dynamics, epistatic interactions, and biological information
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Evolutionary dynamics, epistatic interactions, and biological information
چکیده انگلیسی

We investigate a definition of biological information that connects population genetics with the tools of information theory by focusing on the distribution of genotypes found in a population. Previous research has treated loci as non-interacting by making specific approximations in the calculation of information-theoretic quantities. We expand earlier mathematical forms to include epistasis, or interactions between mutations at all pairs of loci. Application of our improved measure of biological information to evolution on two-locus, two-allele fitness landscapes demonstrates that mutual information between loci reflects epistatic interaction of mutations. Finally, we consider four-locus, two-allele fitness landscapes with modular structure. As modular interactions are inherently epistatic, we demonstrate that our refined approximation provides insight into the underlying structure of these non-trivial fitness landscapes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 266, Issue 4, 21 October 2010, Pages 584–594
نویسندگان
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