کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4498187 | 1318968 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elucidating the protein cold-adaptation: Investigation of the parameters enhancing protein psychrophilicity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
To investigate the role of the critical parameters in adaptation of proteins to low temperatures, a comparative systematic analysis was performed. Several parameters were proposed to have contribution to cold adaptation of proteins. Among proposed parameters, total values of residual structure states, secondary structure states and oligomeric states were alike in both psychrophilic and mesophilic proteins. In addition, our results provided new quantitative information about the trends in the substitution preference of Ile, Phe, Tyr, Lys, Arg, His, Glu and Leu with most of amino acids and substitution avoidance of Gly, Thr and Ala with most of amino acids. These findings would help future efforts propose a strategy for designing psychrophilic proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 255, Issue 1, 7 November 2008, Pages 113-118
Journal: Journal of Theoretical Biology - Volume 255, Issue 1, 7 November 2008, Pages 113-118
نویسندگان
Mina Jahandideh, Seyyed Mohsen Hosseini Barkooie, Samad Jahandideh, Parviz Abdolmaleki, Mohammad Mehdi Movahedi, Somayyeh Hoseini, Ebrahim Barzegari Asadabadi, Fatemeh Javani Jouni, Zahra Karami, Nader Hodjati Firoozabadi,