کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4498476 | 1318984 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A mathematical model of spontaneous calcium(II) oscillations in astrocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Astrocytes exhibit oscillations and waves of Ca2+ ions within their cytosol and it appears that this behavior helps facilitate the astrocyte's interaction with its environment, including its neighboring neurons. Often changes in the oscillatory behavior are initiated by an external stimulus such as glutamate, recently however, it has been observed that oscillations are also initiated spontaneously. We propose here a mathematical model of how spontaneous Ca2+ oscillations arise in astrocytes. This model uses the calcium-induced calcium release and inositol cross-coupling mechanisms coupled with a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model. By computationally mimicking experimental constraints we have found that this model provides results that are qualitatively similar to experiment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 251, Issue 4, 21 April 2008, Pages 553-560
Journal: Journal of Theoretical Biology - Volume 251, Issue 4, 21 April 2008, Pages 553-560
نویسندگان
Maxim Lavrentovich, Sheryl Hemkin,