کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499097 | 1319014 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Asymptotic states and topological structure of an activation-deactivation chemical network
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Asymptotic states and topological structure of an activation-deactivation chemical network Asymptotic states and topological structure of an activation-deactivation chemical network](/preview/png/4499097.png)
چکیده انگلیسی
The influence of the topology on the asymptotic states of a network of interacting chemical species has been studied by simulating its time evolution. Random and scale-free networks have been designed to support relevant features of activation-deactivation reactions networks (mapping signal transduction networks) and the system of ordinary differential equations associated to the dynamics has been numerically solved. We analysed stationary states of the dynamics as a function of the network's connectivity and of the distribution of the chemical species on the network; we found important differences between the two topologies in the regime of low connectivity. In particular, only for low connected scale-free networks it is possible to find zero activity patterns as stationary states of the dynamics which work as signal off-states. Asymptotic features of random and scale-free networks become similar as the connectivity increases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 245, Issue 3, 7 April 2007, Pages 423-432
Journal: Journal of Theoretical Biology - Volume 245, Issue 3, 7 April 2007, Pages 423-432
نویسندگان
Carlotta Martelli, Andrea Giansanti, Ivan Arisi, Vittorio Rosato,