کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4499097 1319014 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymptotic states and topological structure of an activation-deactivation chemical network
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Asymptotic states and topological structure of an activation-deactivation chemical network
چکیده انگلیسی
The influence of the topology on the asymptotic states of a network of interacting chemical species has been studied by simulating its time evolution. Random and scale-free networks have been designed to support relevant features of activation-deactivation reactions networks (mapping signal transduction networks) and the system of ordinary differential equations associated to the dynamics has been numerically solved. We analysed stationary states of the dynamics as a function of the network's connectivity and of the distribution of the chemical species on the network; we found important differences between the two topologies in the regime of low connectivity. In particular, only for low connected scale-free networks it is possible to find zero activity patterns as stationary states of the dynamics which work as signal off-states. Asymptotic features of random and scale-free networks become similar as the connectivity increases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 245, Issue 3, 7 April 2007, Pages 423-432
نویسندگان
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