کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499320 | 1319025 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipid domain boundaries as prebiotic catalysts of peptide bond formation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
To address central problems in the origin of life such as the formation of linear polymers composed of only a small number of types of molecules, we have modeled the distribution of peptides in lipid monolayers. We show that short peptides and amino acids accumulate at the boundary between lipid domains, and that the concentration towards the boundary is higher the longer the peptide. We invoke a constraint on diffusion to one dimension as well as on orientation to suggest that polymerization of peptides is more likely to occur at the domain boundary than within domains or in the bulk phase. In a simple model, in which polymerization is taken to occur only at the boundary, we show that the equilibrium distribution of polymer lengths is shifted towards longer peptides. Since the reaction is occurring in a partially non-aqueous environment, hydrolysis is reduced and condensation increased to yield a significant polymerization. We show also that the free energy change from the redistribution of peptides within domains is sufficient to drive the formation of the peptide bond.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 246, Issue 1, 7 May 2007, Pages 176-185
Journal: Journal of Theoretical Biology - Volume 246, Issue 1, 7 May 2007, Pages 176-185
نویسندگان
D.J. Raine, V. Norris,