کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4499538 | 1319034 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Relationships between the folding rate constant and the topological parameters of small two-state proteins based on general random walk model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this paper, we propose an analytically tractable model of protein folding based on one-dimensional general random walk. A second-order differential equation for the mean folding time of a single protein is constructed which can be used to derive the observed relationship between the folding rate constant and the number of native contacts. The parameters appearing in the model can be determined by fitting the theoretical prediction to the experimental result. In addition, taking into account the fact that the number of native contacts is almost proportional to the relative contact order, we can also explain the observed relationship between the folding rate constant and the relative contact order.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 241, Issue 1, 7 July 2006, Pages 152–157
Journal: Journal of Theoretical Biology - Volume 241, Issue 1, 7 July 2006, Pages 152–157
نویسندگان
Dong Mi, G.R. Liu, J.-S. Wang, Z.R. Li,