کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4512296 1624827 2016 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical structures, biosynthesis, bioactivities, biocatalysis and semisynthesis of tobacco cembranoids: An overview
ترجمه فارسی عنوان
ساختارهای شیمیایی، بیوسنتز، عملکردهای زیستی، بیو کاتالیز و نیمه استنشاق اسمبانوئید های تنباکو: یک مرور کلی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
چکیده انگلیسی


• Cembranoids are mainly found in plants of the Nicotiana and Pinus genera, as well as in soft coral and other marine organisms.
• We summarise the chemical structures and biosynthetic pathways of tobacco cembranoids, and factors influencing their accumulation.
• Tobacco cembranoids are known to display antimicrobial, anti-tumour and neuroprotective properties, which make them excellent templates for the future development of drugs to treat AIDS, cancer and neurodegenerative diseases.
• A large number of bioactive compounds have been prepared from the biocatalysis and semisynthesis of tobacco cembranoids.

Cembranoids, 14-membered carbocyclic diterpenes composed of four isoprene units, are mainly found in plants of the Nicotiana and Pinus genera, as well as in soft coral and other marine organisms. We summarise the chemical structures of the eighty-seven naturally occurring tobacco cembranoids (1–52), nor-cembranoids (53–74), seco-cembranoids (75–82) and cyclised cembranoids (83–87) reported to date. The most prevalent cembranoids in tobacco are (1S,2E,4S,7E,11E)-cembra-2,7,11-triene-4,6-diol (1) and (1S,2E,4R,7E,11E)-cembra-2,7,11-triene-4,6-diol (2), which are biosynthesised in the plastid from the reactions of geranylgeranyl diphosphate with cembrantrien-ol synthase and cytochrome P450 hydroxylase via the 2-C-methyl-D-erythritol-4-phosphate metabolic pathway. The accumulation of cembranoids in tobacco is affected by genetic and environmental factors, including fertiliser, water and light exposure, soil-type and temperature. Tobacco-derived cembranoids are known to display antifungal, antibacterial, anti-human immunodeficiency virus, anti-tumour and neuroprotective properties. A large number of biologically active (primarily anti-invasive, anti-proliferative, anti-migratory and neuroprotective) compounds have been prepared from the semisynthesis of tobacco cembranoids, many via biocatalytic methods. The documented bioactivities of tobacco cembranoids make them excellent templates for the future development of drugs to treat cancer, AIDS, Alzheimer’s disease, Parkinson’s disease, stroke and other neurodegenerative diseases. These findings indicated that although tobacco has long been associated with negative effects on human health, it may ultimately be able to play a therapeutic role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Industrial Crops and Products - Volume 83, May 2016, Pages 66–80
نویسندگان
, , , , , , , ,