کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4512766 1624837 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of in vitro degradation of cellulose acetate membranes modified and incorporated with tetracycline for use as an adjuvant in periodontal reconstitution
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
پیش نمایش صفحه اول مقاله
Study of in vitro degradation of cellulose acetate membranes modified and incorporated with tetracycline for use as an adjuvant in periodontal reconstitution
چکیده انگلیسی


• Absorbable cellulose acetate membrane used in periodontal reconstitutions.
• Dependence of the properties with the degree of substitution (DS).
• Deacetylation increases crystallinity and interaction with water.
• The membrane degradation is increased after impregnation with tetracycline.
• The membrane is absorbable in up to 99 days and works as a drug delivery device.

Commercial cellulose diacetate (DS = 2.45) was partially deacetylated to an appropriate degree of substitution and, after being embedded with tetracycline, was evaluated both as a device for controlled drug release and as an absorbable (degradable) barrier for use as an adjuvant in periodontal reconstitution. The kinetics of both processes were studied in vitro, showing that the process of release fit perfectly to a pseudo-second order model, with rapid desorption in the first 8 h, then slow release for up to 96 h. The estimated degradation time of the membrane was 99 days. Both results indicate the potential of using this membrane as a degradable drug release device.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Industrial Crops and Products - Volume 72, 15 October 2015, Pages 2–6
نویسندگان
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