A strong antioxidant isolated from grapefruit juice retentate

A new furanocoumarin, 4-hydroxy-9-(3,7-dimethylocta-1,6-dien-3-yl)-7H-furo [3,2-g] chromen-7-one (for convenience, temporarily designated as GF-338), was isolated and characterized from grapefruit juice retentate using different chromatography and spectra techniques. At the final concentration of 10 μmol/L in the reaction system, GF-338 showed 8.53±0.35% 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging activity while Vitamin C only showed 4.32±0.25%, which demonstrated that GF-338 is a potential strong antioxidant. Its other bioactivities remain to be evaluated.