Molecular communication: Harnessing biochemical materials to engineer biomimetic communication systems

Molecular communication uses molecules (i.e., biochemical signals) as an information medium and allows biologically and artificially created nano- or microscale entities to communicate over a short distance. It is a new communication paradigm; it is different from the traditional communication paradigm, which uses electromagnetic waves (i.e., electronic and optical signals) as an information medium. Key research challenges in molecular communication include design of system components (i.e., a sender, a molecular propagation system, a receiver, and a molecular communication interface) and mathematical modeling of each system component as well as entire systems. We review all research activities in molecular communication to date, from its origin to recent experimental studies and theoretical approaches for each system component. As a model molecular communication system, we describe an integrated system that combines a molecular communication interface (using a lipid vesicle embedded with channel-forming proteins), a molecular propagation system (using microtubule motility on kinesin molecular motors and DNA hybridization), and a sender/receiver (using giant lipid vesicles embedded with gemini-peptide lipids). We also present potential applications and the future outlook of molecular communication.