کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4645017 1632178 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of optimal control to the cardiac defibrillation problem using a physiological model of cellular dynamics
ترجمه فارسی عنوان
استفاده از کنترل مطلوب به مشکل دفیبریلسیون قلب با استفاده از یک مدل فیزیولوژیکی دینامیک سلولی
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات محاسباتی
چکیده انگلیسی

Optimal control techniques are investigated with the goal of terminating reentry waves in cardiac tissue models. In this computational study the Luo–Rudy phase-I ventricular action potential model is adopted which accounts for more biophysical details of cellular dynamics as compared to previously used phenomenological models. The parabolic and ordinary differential equations are solved as a coupled system and an AMG preconditioner is used to solve the discretized elliptic equation. The numerical results demonstrate that defibrillation is possible by delivering a single strong shock. The optimal control approach also leads to successful defibrillation and demands less total current. The present study motivates us to further investigate optimal control techniques on realistic geometries by incorporating the structural heterogeneity in the cardiac tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Numerical Mathematics - Volume 95, September 2015, Pages 130–139
نویسندگان
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