کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
466570 | 697855 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epithelial to mesenchymal transition—The roles of cell morphology, labile adhesion and junctional coupling
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Epithelial to mesenchymal transition—The roles of cell morphology, labile adhesion and junctional coupling Epithelial to mesenchymal transition—The roles of cell morphology, labile adhesion and junctional coupling](/preview/png/466570.png)
چکیده انگلیسی
Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell–matrix adhesion in addition to modulating cell–cell adhesion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 111, Issue 2, August 2013, Pages 435–446
Journal: Computer Methods and Programs in Biomedicine - Volume 111, Issue 2, August 2013, Pages 435–446
نویسندگان
Tariq Abdulla, Luis Luna-Zurita, José Luis de la Pompa, Jean-Marc Schleich, Ron Summers,