کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4752390 | 1416135 | 2017 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy](/preview/png/4752390.png)
چکیده انگلیسی
Theranostic agent of PFOB@IR825-HA-Cy5.5 NPs was successfully fabricated. PFOB showed good capability to absorb the X-rays, Cy5.5 on the outer surface acted as fluorescent probe, while IR825 in the core as photothermal agent. By utilizing the fluorescence quench effect of the two dyes and degradability of HA by hyaluronidase (Hyal-1) in the tumor, strong fluorescence enhancement could be achieved to delineate the tumor more clearly. Such theranostic agent demonstrated excellent diagnostics capability without compromising the photothermal therapy efficacy, and can be utilized as an active targeting agent for triple X-ray computed tomography (CT), photoacoustic and activatable fluorescence imaging guided photothermal ablation of tumors.217
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 132, July 2017, Pages 72-84
Journal: Biomaterials - Volume 132, July 2017, Pages 72-84
نویسندگان
Xiaolong Liang, Lei Fang, Xiaoda Li, Xu Zhang, Fan Wang,