Reaction based colorimetric and fluorescence probes for selective detection of hydrazine

- Two fluorescent probes based on BODIPY fluorophore and Gabriel reaction for hydrazine were developed.
- Both fluorescent probes exhibit good sensitivity and selectivity to hydrazine in aqueous medium.
- The fluorescent probes showed different reactivity with hydrazine.

Development of simple and selective methods for the detection of hydrazine has attracted much attention, because hydrazine is harmful to human organs and is a probable human carcinogen. As presented in this work, two new colorimetric and fluorescent probes (HP1 and HP2) for hydrazine based on dipyrromethene boron difluoride (BODIPY) fluorophore were synthesized and characterized, which showed different reactivity with hydrazine through Gabriel reaction mechanism. In the case of HP1, the hydrazinelysis occurred completely and lead to an enhanced fluorescence that is due to the released N-protecting group. However, the hydrazinelysis of HP2 did not reach its completion, where the additioned hydrazine group caused efficient PET quenching, resulting in a decreased fluorescence. Both probes displayed good sensitivity and selectivity to hydrazine in aqueous medium.

152