POSS supported C2-symmetric bisprolinamide as a recyclable chiral catalyst for asymmetric Aldol reaction

• The new POSS that supported the prolinamide-type catalysts was synthesized and used to catalyze asymmetric Aldol reactions.
• The higher ee value has been obtained after the C2-symmetric bisprolinamide chrial catalyst was immobilized onto the POSS.
• The POSS supported catalyst could be recycled simply and reused in five consecutive cycles maintaining its effectiveness.

POSS supported prolinamide-type catalysts were synthesized and used to catalyze asymmetric Aldol reactions between unmodified ketones and aldehydes. Immobilization of the prolinamide-type catalysts onto POSS resulted in good yields and improved diastereoselectivity as well as enantioselectivity. The POSS-supported catalysts were recycled simply by precipitation and filtration, and could be reused in five consecutive cycles without losing its effectiveness.