|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|49278||46731||2016||4 صفحه PDF||سفارش دهید||دانلود رایگان|
• Bio-based solvent glycerol was used for ampicillin synthesis.
• An ampicillin yield of 93.5% was achieved at low acyl donor/nucleophile ratio (1.05:1).
• 1.12 mol acyl donor D-PGME was required to produce 1 mol ampicillin.
To fulfill the industry demand of ampicillin enzymatic synthesis, immobilized mutant Penicillin G acylase and bio-based solvent glycerol were employed at high substrate concentration and low acyl donor/nucleophile ratio. After process optimization, good yield and low operation costs were achieved.
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Journal: Catalysis Communications - Volume 79, 5 April 2016, Pages 31–34