Calcium catalyzed Mukaiyama–Mannich addition of silyl enol ethers to nitrones

• Calcium catalyzed addition of ketone-derived silyl enol ethers to N-phenyl nitrones
• Use of commercially available calcium(II) complex.
• Calcium(II) is a relatively cheap, abundant, benign metal.
• Synthesis of β-(silyloxy)amino carbonyl compounds

A method for synthesizing β-(silyloxy)amino carbonyls through the addition of ketone-derived silyl enol ethers to N-phenyl nitrones has been developed. The transformation is catalyzed by a commercially available calcium(II) complex affording β-(silyloxy)amino carbonyls in good to excellent yield.

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