کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932711 | 1433528 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
ترجمه فارسی عنوان
فراوانی و تاثیر عوامل خطر ابتلا به زوال عقل در بیماری آلزایمر پرونده
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 56, August 2017, Pages 33-40
Journal: Neurobiology of Aging - Volume 56, August 2017, Pages 33-40
نویسندگان
Isabelle Bos, Stephanie J. Vos, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckhart Rüther, Sebastiaan Engelborghs, Ellis Niemantsverdriet, Ellen Elisa De Roeck, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen,