کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4932784 | 1433533 | 2017 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults
ترجمه فارسی عنوان
ریزنشت شبکیه به طور منحصر به فرد با آتروفی لوب میانی در افراد مسن عادی و سالم
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کلمات کلیدی
سالخورده، بیماری آلزایمر، توموگرافی انسجام نوری، بیماری نوروژنیک، کم خونی تصویربرداری شبکیه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Given the converging pathologic and epidemiologic data indicating a relationship between retinal integrity and neurodegeneration, including Alzheimer's disease (AD), we aimed to determine if retinal structure correlates with medial temporal lobe (MTL) structure and function in neurologically normal older adults. Spectral-domain optical coherence tomography, verbal and visual memory testing, and 3T-magnetic resonance imaging of the brain were performed in 79 neurologically normal adults enrolled in a healthy aging cohort study. Retinal nerve fiber thinning and reduced total macular and macular ganglion cell volumes were each associated with smaller MTL volumes (ps < 0.04). Notably, these markers of retinal structure were not associated with primary motor cortex or basal ganglia volumes (regions relatively unaffected in AD) (ps > 0.70), or frontal, precuneus, or temporoparietal volumes (regions affected in later AD Braak staging ps > 0.20). Retinal structure was not significantly associated with verbal or visual memory consolidation performances (ps > 0.14). Retinal structure was associated with MTL volumes, but not memory performances, in otherwise neurologically normal older adults. Given that MTL atrophy is a neuropathological hallmark of AD, retinal integrity may be an early marker of ongoing AD-related brain health.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 51, March 2017, Pages 141-147
Journal: Neurobiology of Aging - Volume 51, March 2017, Pages 141-147
نویسندگان
Kaitlin B. Casaletto, Michael E. Ward, Nicholas S. Baker, Brianne M. Bettcher, Jeffrey M. Gelfand, Yaqiao Li, Robert Chen, Shubir Dutt, Bruce Miller, Joel H. Kramer, Ari J. Green,