Amino acid ionic liquid bound copper Schiff base catalyzed highly efficient three component A3-coupling reaction

• First catalytic application of copper Schiff base complexed amino acid ionic liquid
• Reusable catalyst for A3 coupling reaction
• One-pot synthesis of propargylamines via multicomponent coupling reaction
• Environmentally benign ionic liquid for organic transformation
• Facile recovery and consistent recyclability of the catalyst

Amino acid ionic liquid Schiff base derived from dl-threonine and salicylaldehyde was complexed with copper (II) ions and used as an efficient and reusable catalyst for multicomponent synthesis of propargylamines via A3 coupling of aldehydes, amines, and alkynes. The ionic liquid derived catalyst was readily synthesized, reusable and exhibited superior catalytic activity. The synthesized catalyst showed consistent activity for several runs without any significant loss in activity and importantly, no leaching had occurred during this course.

Figure optionsDownload as PowerPoint slide