کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4933959 | 1433886 | 2017 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The association between in vivo central noradrenaline transporter availability and trait impulsivity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The association between in vivo central noradrenaline transporter availability and trait impulsivity The association between in vivo central noradrenaline transporter availability and trait impulsivity](/preview/png/4933959.png)
چکیده انگلیسی
The brain noradrenaline (NA) system, particularly NA transporters (NAT), are thought to play an important role in modulating impulsive behavior. Impaired impulsivity is implicated in a variety of neuropsychiatric conditions; however, an in vivo link between central NAT availability and human impulsivity has not been shown. Using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB), we tested whether NAT availability is associated with this basic behavioral trait based on the Barratt Impulsiveness Scale (BIS-11) in twenty healthy individuals (12 females, 33.8±9.3, 21-52 years of age) with a body mass index (BMI) ranging from 21.7 kg/m2 to 47.8 kg/m2. Applying both voxel-wise and volume-of-interest (VOI) based analyses, we found that distribution volume ratios (DVR) used as PET outcome measures negatively correlated with BIS-11 total scores in the orbitofrontal cortex (OFC) and in the hippocampus as well as in parts of the cerebellar cortex. These associations however did not remain after correction for multiple testing. Thus, although it appears that low NAT availability is associated with greater scores of impaired behavioral control, this needs to be confirmed in a larger series of individuals with highly impulsive behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 267, 30 September 2017, Pages 9-14
Journal: Psychiatry Research: Neuroimaging - Volume 267, 30 September 2017, Pages 9-14
نویسندگان
Swen Hesse, Ulrich Müller, Michael Rullmann, Julia Luthardt, Anke Bresch, Georg-Alexander Becker, Franziska Zientek, Marianne Patt, Philipp M. Meyer, Matthias Blüher, Maria StrauÃ, Wiebke Fenske, Mohammed Hankir, Yu-Shin Ding, Anja Hilbert,