کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4934042 1433896 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SREBF-2 polymorphism influences white matter microstructure in bipolar disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
SREBF-2 polymorphism influences white matter microstructure in bipolar disorder
چکیده انگلیسی


- rs1052717 polymorphism influence measures of white matter integrity in BD.
- rs11868035 is not associated with measures of white matter integrity in BD.
- SREBF-2 polymorphism seems to influence white matter microstructure in BD.
- SREBP pathway could play a role in CNS myelination processes.

The aim of the study is to investigate if gene polymorphisms in sterol regulatory element binding protein transcriptional factors SREBF-1 and SREBF-2, which regulate lipid and cholesterol metabolism, could affect white matter (WM) microstructure, the most recognized structural biomarker of bipolar disorder (BD). In a sample of 93 patients affected by BD, we investigated the effect of SREBF-1 rs11868035, and SREBF-2 rs1052717, on WM microstructure, using diffusion tensor imaging and tract-based spatial statistics. We observed increased radial diffusivity in the rs1052717 A/A genotype compared to A/G and G/G, and reduced fractional anisotropy (FA) in the rs1052717 A/A genotype compared to G carriers in cingulum, corpus callosum, superior and inferior longitudinal fasciculi, and anterior thalamic radiation. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in BD and therefore a possible role of SREBP pathway in CNS myelination processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 257, 30 November 2016, Pages 39-46
نویسندگان
, , , , , ,