کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4934044 1433896 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cortical inhibitory deficits in Huntington's disease are not influenced by gender
ترجمه فارسی عنوان
نقص مهلک کورتیک در بیماری هانتینگتون تحت تأثیر جنس نیست
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
Huntington's disease (HD) affects GABA-mediated inhibitory circuitry in the cortex. As there is evidence that sex hormones affect GABAergic function, we investigated whether gender modulates GABA-related pathophysiological changes in HD. Fifteen premanifest HD, 11 symptomatic HD and 16 healthy control participants were assessed with paired-pulse transcranial magnetic stimulation applied to the primary motor cortex. Cortical inhibition was significantly reduced in symptomatic HD, compared with premanifest HD and controls. There was reduced inhibition in females overall, but no Group-by-Sex interaction. These findings suggest that sex hormones do not exert a direct influence on the mechanisms underpinning cortical inhibitory deficits in HD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 257, 30 November 2016, Pages 1-4
نویسندگان
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