کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4934068 1433894 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects
ترجمه فارسی عنوان
اختلافات ساختاری در حوزه های هیپوکامپ در بین بیماران اسکیزوفرنیا، بیماران افسردگی عمده و افراد سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- We detected volume reductions of CA1 and the dentate gyrus in schizophrenia.
- Schizophrenia patients showed lower DG volume than MDD patients.
- The clinical severities were nominally related to the hippocampal volumes.

Many MRI studies have reported a volume reduction of the hippocampus in psychiatric diseases. However, disease-related volume differences in hippocampus subfields remain unclear. Here we compared the volumes of hippocampus subfields in patients with schizophrenia, patients with major depressive disorder (MDD), and healthy subjects as controls. T2-weighted images were acquired in 20 patients with schizophrenia, 36 with MDD, and 35 healthy volunteers by 3-Tesla MRI. Hippocampal subfields were segmented using an automatic algorithm, Automatic Segmentation of Hippocampal Subfields (ASHS). Schizophrenia patients exhibited significant volume reductions in the cornu ammonis (CA)1 compared to the controls, and in the dentate gyrus compared to the controls and MDD patients without medication, whereas there was no significant difference between the MDD patients and controls. There was a nominal negative correlation between the perirhinal cortex volume and depression severity in the MDD patients without medication, whereas there were negative correlations between CA2 volume and both negative symptoms and the duration of illness in the schizophrenia patients. We identified differing volume reductions in hippocampal subfields and varying correlations between disease severity and subfield volumes depending on diagnosis, suggesting that volume differences in hippocampus subfields may provide important information regarding the pathophysiology of schizophrenia and MDD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 259, 30 January 2017, Pages 54-59
نویسندگان
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