DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia

- We found microstructural differences between adolescent COS siblings and age-matched control participants with greater mean diffusivity (MD) in the putamen in controls compared to COS siblings.
- Our data also reveal widespread increased white matter MD, radial diffusivity (RD), and axial diffusivity (AD) throughout the brain in the COS siblings compared to controls.
- Increases in white matter fractional anisotropy (FA) and decreases in MD, RD, and AD were associated with worse task performance in COS siblings.