کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4934076 | 1433895 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinct differences in striatal dysmorphology between attention deficit hyperactivity disorder boys with and without a comorbid reading disability
ترجمه فارسی عنوان
تفاوت های متفاوتی در اختلال دوقطبی در میان اختلال بیش فعالی کمبود توجه با پسران با و بدون معلولیت خواندن هماهنگ
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
There is evidence of greater cognitive deficits in attention deficit hyperactivity disorder with a comorbid reading disability (ADHD/+RD) compared to ADHD alone (ADHD/âRD). Additionally, the striatum has been consistently implicated in ADHD. However, the extent of morphological alterations in the striatum of ADHD/+RD is poorly understood, which is the main purpose of this study. Based on structural MRI images, the surface deformation of the caudate and putamen was assessed in 59 boys matching in age and IQ [19 ADHD/âRD, 15 ADHD/+RD and 25 typically developing controls (TDC)]. A vertex based analysis with multiple comparison correction was conducted to compare ADHD/âRD and ADHD/+RD to TDC. Compared to TDC, ADHD/+RD showed multiple bilateral significant clusters of surface compression. In contrast, ADHD/âRD showed fewer significant clusters of surface compression and restricted to the left side. Regarding the putamen, only ADHD/âRD showed significant clusters of surface compression. Results demonstrate for the first time a greater extent of morphological alterations in the caudate of ADHD/+RD than ADHD/âRD compared to TDC, which may suggest greater implicated cortical areas projecting to the caudate that are associated with the greater neuropsychological impairments observed in ADHD/+RD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 258, 30 December 2016, Pages 30-36
Journal: Psychiatry Research: Neuroimaging - Volume 258, 30 December 2016, Pages 30-36
نویسندگان
Dhruman D. Goradia, Sherry Vogel, Brianne Mohl, Dalal Khatib, Caroline Zajac-Benitez, Usha Rajan, Arthur Robin, David R. Rosenberg, Jeffrey A. Stanley,