A copper-free Sonogashira reaction using nickel ferrite as catalyst in water

• Nickel ferrite nanoparticles were applied successfully in a Sonogashira reaction.
• Reactions were performed under green conditions using water as a solvent.
• All the reactions were completed in short times with excellent yields.
• The magnetic catalyst can be separated easily using an external magnetic field.
• The catalyst is recyclable and reusable without activity lost.

The Sonogashira reaction using nickel ferrite nanoparticles as catalyst and under copper-free conditions was investigated in water as a green solvent. Various types of aryl and alkyl halides were successfully coupled with phenyl acetylene under the optimized reaction conditions with very good to excellent yields at a short time. The catalyst is easily recoverable and can be reused for several runs with a good turnover number.

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