کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
49502 | 46750 | 2014 | 5 صفحه PDF | دانلود رایگان |

• Reactions were run in a solvent-free system without transition metal or additive.
• Solid NaOH catalyzed N-alkylations of amines with alcohols to the secondary amines.
• The reaction between aniline and benzyl alcohol yielded 99.1 mol% of the product.
• This novel reaction most likely proceeds with a base-catalyzed mechanism.
Different from any other catalytic systems containing transition metals and additives, sodium hydroxide itself was found to be a unique and effective catalyst for the solvent-free synthesis of the secondary amines via the N-alkylation of amines with alcohols. For the reaction of aniline with benzyl alcohol, 99.6 mol% conversion of aniline and 99.5% selectivity of the product were achieved under optimal conditions. Also, high conversion and selectivity could be acquired for the N-alkylations of various amines with alcohols, implying the universality of this methodology. Mechanistic studies revealed that this novel reaction most possibly proceeds with a base-catalyzed mechanism.
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Journal: Catalysis Communications - Volume 55, 5 October 2014, Pages 78–82