A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

• A robust Baeyer-Villiger chemo-enzymatic method for lactone synthesis is described
• The new application of acyltransferase isolated from Mycobacterium smegmatis is proposed
• Acyltransferase exhibited high activity and stability under harsh reaction conditions

The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H2O2 at 45 °C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.

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