Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications

• Perlecan is an essential vascular proteoglycan.
• C-terminal domain V of human perlecan expressed recombinantly as a proteoglycan.
• Silk biomaterials functionalised with recombinant domain V.
• Immobilization technique and glycosaminoglycan chains affected domain V orientation.
• Domain V orientation modulated endothelial cell and platelet interactions.