کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4988733 1455968 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting performance of constant flow depth filtration using constant pressure filtration data
ترجمه فارسی عنوان
پیش بینی عملکرد فیلتر جریان عمق جریان با استفاده از داده های تصفیه فشار ثابت
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
چکیده انگلیسی


- Identifies best classic and combined fouling models describing depth filtration.
- Utilization of calculated fouling coefficients to build a predictive model.
- Utilization of constant pressure flux decline data to predict constant flow capacity.
- Proposed method reduces material and time requirements for filter sizing studies.
- Method validated for centrates processed at different scales across multiple products.

This paper describes a method of predicting constant flow filtration capacities using constant pressure datasets collected during the purification of several monoclonal antibodies through depth filtration. The method required characterisation of the fouling mechanism occurring in constant pressure filtration processes by evaluating the best fit of each of the classic and combined theoretical fouling models. The optimised coefficients of the various models were correlated with the corresponding capacities achieved during constant flow operation at the specific pressures performed during constant pressure operation for each centrate. Of the classic and combined fouling models investigated, the Cake-Adsorption fouling model was found to best describe the fouling mechanisms observed for each centrate at the various different pressures investigated. A linear regression model was generated with these coefficients and was shown to predict accurately the capacities at constant flow operation at each pressure. This model was subsequently validated using an additional centrate and accurately predicted the constant flow capacities at three different pressures (0.69, 1.03 and 1.38 bar). The model used the optimised Cake-Adsorption model coefficients that best described the flux decline during constant pressure operation. The proposed method of predicting depth filtration performance proved to be faster than the traditional approach whilst requiring significantly less material, making it particularly attractive for early process development activities.

312

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 531, 1 June 2017, Pages 138-147
نویسندگان
, , , , , , ,