Identification of Functional Connections in Biological Neural Networks Using Dynamic Bayesian Networks

Investigation of the underlying structural characteristics and network properties of biological networks is crucial to understanding the system-level regulatory mechanism of network behaviors. A Dynamic Bayesian Network (DBN) identification method is developed based on the Minimum Description Length (MDL) to identify and locate functional connections among Pulsed Neural Networks (PNN), which are typical in synthetic biological networks. A score of MDL is evaluated for each candidate network structure which includes two factors: i) the complexity of the network; and ii) the likelihood of the network structure based on network dynamic response data. These two factors are combined together to determine the network structure. The DBN is then used to analyze the time-series data from the PNNs, thereby discerning causal connections which collectively show the network structures. Numerical studies on PNN with different number of nodes illustrate the effectiveness of the proposed strategy in network structure identification.