Iron oxide catalyzed reduction of acid chlorides to aldehydes with hydrosilanes

• We have developed the ion oxide catalyzed reducion of acid chlorides to aldehyds.

Iron-catalyzed reduction of acid chlorides to the corresponding aldehydes with a hydrosilane as a reducing agent has been developed. A simple mixture of a commercially available iron oxide (FeO) and tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) as a catalyst realized the reduction of acid chlorides to the corresponding aldehydes under mild reaction conditions.

Iron-catalyzed reduction of acid chlorides to the corresponding aldehydes with a hydrosilane as a reducing agent has been developed. A simple mixture of a commercially available iron oxide (FeO) and tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) as a catalyst realized the reduction of acid chlorides (1) to the corresponding aldehydes (2) under mild reaction conditions.Figure optionsDownload as PowerPoint slide