Lipase-catalyzed kinetic resolution of 3-phenyloxazolidin-2-one derivatives: Cascade O- and N-alkoxycarbonylations

• A lipase-catalyzed, cascade kinetic resolution protocol has been established.
• Enantiopure 3-phenyloxazolidin-2-one derivatives have been synthesized.
• Candida antarctica Lipase B showed high catalytic activity and stereoselectivity.

A lipase-catalyzed, cascade kinetic resolution protocol has been established for the synthesis of 3-phenyloxazolidin-2-one derivatives with up to excellent enantioselectivities (95% ee). Candida antarctica lipase B showed high catalytic activity and stereoselectivity in sequential O- and N-alkoxycarbonylation processes.

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