کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5011438 1462590 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic dynamics regulation in response to high frequency stimulation in neuronal networks
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی مکانیک
پیش نمایش صفحه اول مقاله
Synaptic dynamics regulation in response to high frequency stimulation in neuronal networks
چکیده انگلیسی
High frequency stimulation (HFS) has confirmed its ability in modulating the pathological neural activities. However its detailed mechanism is unclear. This study aims to explore the effects of HFS on neuronal networks dynamics. First, the two-neuron FitzHugh-Nagumo (FHN) networks with static coupling strength and the small-world FHN networks with spike-time-dependent plasticity (STDP) modulated synaptic coupling strength are constructed. Then, the multi-scale method is used to transform the network models into equivalent averaged models, where the HFS intensity is modeled as the ratio between stimulation amplitude and frequency. Results show that in static two-neuron networks, there is still synaptic current projected to the postsynaptic neuron even if the presynaptic neuron is blocked by the HFS. In the small-world networks, the effects of the STDP adjusting rate parameter on the inactivation ratio and synchrony degree increase with the increase of HFS intensity. However, only when the HFS intensity becomes very large can the STDP time window parameter affect the inactivation ratio and synchrony index. Both simulation and numerical analysis demonstrate that the effects of HFS on neuronal network dynamics are realized through the adjustment of synaptic variable and conductance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Communications in Nonlinear Science and Numerical Simulation - Volume 55, February 2018, Pages 29-41
نویسندگان
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