Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction

• Efficient modified Skraup reaction and Bamberger rearrangement
• Modified Skraup reaction without As2O5
• Synthesis of 6-hydroxyquinoline under microwave irradiation conditions
• Synthesis of 6-hydroxyquinoline via a domino reaction

An efficient and modified Skraup reaction and Bamberger rearrangement in neat water were developed using nitrobenzene and an inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions was furnish regioselectively to the 6-hydroxyquinoline. The target compound was obtained in 77% yield via efficient domino reaction with a “one pot eleven steps”.

Figure optionsDownload as PowerPoint slide