Preparation of Pomegranate Ellagic Acid Inclusion Complex Gel and Its Transdermal Permeation in Vitro

The aim of the present work was to select the best formulation of pomegranate ellagic acid-hydroxypropyl-β-cyclodextrin (PEA-HP-β-CD), and to compare the transcutaneous permeation of PEA-HP-β-CD inclusion compound gel with the free drug in gel. The PEA-HP-β-CD inclusion complex was prepared by stirring-ultrasonic method; the change of PEA content was used as the stability index, and orthogonal design was used to establish the best prescription. The permeation flux of PEA in the recipient fluid and the amount of retained drug in the skin were measured by permeation test in vitro. Inclusion gel has moderate viscosity and good stability when pH was 5.5, propylene glycol as co-solvent 10 mL, substrate Carbomer-940 was 1.5 g in the amount of per 100 g gelling agent. The present findings suggest that PEA-HP-β-CD inclusion compound was initially formed, the inclusion compound gel was reasonable in design and stable in process. The inclusion complexes, with PEA as carrier and carbomer matrix gel, enhanced drug effects on skin tissue.