کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032496 1369984 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetics of charged antibiotic penetration into human intervertebral discs: A numerical study
ترجمه فارسی عنوان
سینتیک نفوذ آنتی بیوتیک به دیسک بین مهره ای انسان: یک مطالعه عددی
کلمات کلیدی
دیسک بین مهره ای، نفوذ آنتی بیوتیک، پدیده حمل و نقل، تئوری مخلوط، تجزیه و تحلیل عنصر محدود، عفونت دیسک،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from z=+2 (positively charged) to z=−2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 49, Issue 13, 6 September 2016, Pages 3079-3084
نویسندگان
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