Ion-paired pirenzepine-loaded micelles as an ophthalmic delivery system for the treatment of myopia

The PRZ micelles are characterized by their unique core-shell structures, in which hydrophobic segments (PDLLA) are segregated from the aqueous exterior to form an inner core surrounded by hydrophilic segments (mPEG). The formed PRZ/SA ion pairs with the increased hydrophobicity upon the addition of SA can be either loaded within the micelles or absorbed on the shells of the micelles, which ultimately leads to increased loading efficiency, better corneal permeability and improved in vivo absorption.229