NF-κB inhibitors that prevent foam cell formation and atherosclerotic plaque accumulation

Fullerene derivatives are powerful anti-oxidants capable of significantly reducing the incidence and burden of inflammatory disorders. In the current study we show that fullerene derivatives reduce atherosclerosis of aortic arches of mice as well as a general protective effect when challenged with high fat diets. Taken together, these results are a significant step toward fullerene based therapies for inflammatory diseases.98