Mitochondrial-targeted photosensitizer-loaded folate-albumin nanoparticle for photodynamic therapy of cancer

This study demonstrated that TPP-PheoA@FA-chol-BSA NP was internalized upon cells by endocytosis mechanism due to its active targeting ligand and further reached to mitochondria owing to TPP moiety in TPP-PheoA conjugate. Overall, the antitumor PDT efficacy of TPP-PheoA significantly increased.74