Micropatterning of nanocomposite polymer scaffolds using sacrificial phosphate glass fibers for tendon tissue engineering applications

This study for the first time shows potential of POSS-PCU nanocomposite for tendon repair applications. Micropatterning of the POSS-PCU is achieved by using sacrificial phosphate glass fiber template. This micropattern polymer significantly enhances cellular alignment and biological function of tenocytes compared to unpattern surface, thus bio-mimicking tenocytes microenvironment. This study provides simple, effective and reproducible method of micropatterning polymers for tendon repair applications.116