Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression

In this work, we design a kind of cerium (III) chloride (CeCl3) loaded mesoporous silica (CeCl3@mSiO2) nanoparticles and proved their potential application in preventing the formation of diabetic cataract in vitro and vivo by using a well-established rat model of STZ-induced diabetes. A: the schematic diagram of CeCl3@mSiO2 nanoparticles preparation; B: TEM of mSiO2 nanoparticles (local enlargement of single mSiO2 nanoparticles); C: A line graph, showing the time course of changes cataract degrees in different groups of animals; D: various degrees of cataract and representative images of H&E-stained sections of the lens tissue in experimentally diabetic animals 8 weeks after treatment with vehicle, 10 mg/kg and 20 mg/kg CeCl3@mSiO2 nanoparticles, respectively.200