کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032976 1370003 2017 35 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy
چکیده انگلیسی
Large amino acid transporter 1 highly expressed in tumor cells is selected as a novel target for tumor active-targeting nanoformulation. Glutamate modified LAT1 targeting nanoparticles significantly improve the cytotoxicity, cellular uptake and in vivo antitumor effects. Recycled LAT1 guarantee sufficient transporters on cell membrane for continuous cellular uptake. LAT1 holds a great potential to be used as a high-efficiency target for the rational design of active-targeting nanosystems.316
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 13, Issue 3, April 2017, Pages 987-998
نویسندگان
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