Smuggling gold nanoparticles across cell types - A new role for exosomes in gene silencing

Smuggling gold nanoparticles across cell types. Following administration of AuNP@PEG@anti-RAB27A nanoconjugates, MCF-7 cells decrease release of exosomes due to specific gene silencing. The released exosomes convey gene information to BTEC cells, which in turn are transformed and express breast cancer biomarkers. The same exosomes released by the MCF-7 cells carry the nanoconjugates across to the BTEC cells, where they exert the gene silencing with comparable efficacy as the initial challenge. This way, the exome-mediated traffic of nanoconjugates may follow the same path as the distant transformation of normal into tumor cells.273