Magnetic, but not non-magnetic, reduced graphene oxide in spinal cord increases nociceptive neuronal responsiveness

The administration of highly magnetic nanoparticles in the intrathecal space of rats disturbs the neuronal magnetic field, most likely through the interaction with Cav2+ and subsequent glutamate release. This disturbance induces an increase in neuronal excitability which is observable by the decrease in mechanical nociceptive threshold and increase in paw flinches behavior.111