Evaluation of reconstituted high-density lipoprotein (rHDL) as a drug delivery platform - a detailed survey of rHDL particles ranging from biophysical properties to clinical implications

This work addresses a variety of biophysical, biological and clinical aspects of discoidal reconstituted high-density lipoprotein (rHDL) nanoparticles. The purpose of this broad rHDL investigation is to point out and collect diverse factors that have the potential to advance the rHDL drug delivery vehicle toward realizing the 'magic bullet' for lipophilic and hydrophilic drug delivery in various clinical contexts.117