Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery

a single step process, was utilised to produce cisplatin encapsulated poly (lactic-co-glycolic acid) polymer particles. Control over the size of the particles and loading of cisplatin within the polymeric matrix was facilitated by variation of polymer:drug ratios. The particles were further analysed by SEM-TEM/EDX, FTIR and DSC to confirm the successful encapsulation of cisplatin within the polymeric particles. In order to analyse the mechanism of cisplatin release, in-vitro release tests were performed and it was noted that all the formulations exhibited a two stage release: an initial burst release < 4 h, followed by a sustained release period.157