Ligandless Suzuki–Miyaura reaction in neat water with or without native β-cyclodextrin as additive

Efficient green ligand-free Suzuki cross coupling in neat water was developed by using low loading of catalyst (0.5 mol%) in neat water in the presence or not of β-cyclodextrin (0.5 mol%) as additive at 25 °C and 100 °C respectively.

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► Suzuki cross-coupling reactions using ligand-free palladium Pd(OAc)2
► Suzuki cross-coupling was performed in water.
► The method was applied successfully to a number of brom substituted reactants.
► The presence of a low amount of native b-CD (0.5 mol%)