کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5037610 | 1472495 | 2018 | 14 صفحه PDF | دانلود رایگان |
- We randomized smokers to either stop or continue NRT after a lapse.
- Continuing NRT after a lapse did not increase return to abstinence.
- This may be because both groups quickly regained abstinence and returned to patch.
IntroductionFour post-hoc analyses of prior trials found smokers using nicotine patch following a lapse were less likely to progress to relapse compared to those using a placebo patch following a lapse. We attempted a conceptual replication test of these results via a randomized trial of instructions to continue vs. stop nicotine patch after a lapse.MethodsSmokers trying to quit (n = 701) received nicotine patch (21/14/7 mg) and brief phone counseling (six 15-min sessions). We randomized smokers to receive instructions for and rationale for stopping vs. continuing patch after a lapse. The messages were repeated before and after cessation and following lapses via counseling, phone and written instructions.ResultsAmong those who lapsed, those told to Continue Patch did not have a greater incidence of 7-day abstinence at 4 months (primary outcome) than those told to Discontinue Patch (51% vs. 46%). Most (81%) participants in the Discontinue condition stopped patch for only 1-2 days and then resumed abstinence and patch use. Analyses based on all participants randomized were similar. Adverse events were as expected and did not differ between conditions.ConclusionInstructions to continue nicotine patch after a lapse did not increase return to abstinence. These negative results may have occurred because actual use of patch after a lapse was similar in the two conditions. Also, allowing patch use while smoking may have reduced motivation to stay abstinent.
Journal: Addictive Behaviors - Volume 76, January 2018, Pages 68-81